About the meeting
The 7th DNA Polymerases meeting will take place in Warsaw, Poland, from 28th to 31st of August 2024. It is the next meeting in a series of conferences that take place every two years in different European countries. The first was held in Ascona (Switzerland) in 2010, followed by Madrid (Spain, 2012), Cambridge (UK, 2014), Biarritz (France, 2016) and Leiden (Netherlands, 2018). The last conference was held in 2022 in Stockholm (Sweden). All previous conferences have attracted eminent experts from different parts of the world and have been a great scientific success.
The aim of the conference is to present and discuss the results of the latest research on all relevant aspects of DNA polymerases, including their structure, biochemistry, genetics, role in mutagenesis and pathogenesis, as well as their applications in molecular biology, biotechnology and medicine.
The conference will provide an excellent opportunity to present the latest research on DNA polymerases and bring together a diverse group of leading scientists from around the world.
The DNA Polymerases meeting is a chance to integrate the scientific community in the field and provide an opportunity to freely exchange ideas, establish collaborations, as well as present and discuss the results with a broad panel of specialists.
The conference is co-financed by the Polish Ministry of Education and Science under the ‘Excellent Science’ Programme
(contract no. KONF/SP/0186/2023/01)
Organizers
Iwona Fijalkowska
Justyna McIntyre
Michal Dmowski
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland
Scientific Board
Katarzyna Bebenek
NIEHS
National Institutes of Health
USA
Roger Woodgate
NICHD
National Institutes of Health
USA
Registration and abstract submission
Registration will open December 1st 2023
Registration fee
Early bird registration (deadline March 31st 2024) € 780
Regular registration (deadline August 10th 2024) € 820
Fee covers lunches, dinners and gala dinner, but not the hotel.
Accompanying persons
Accompanying persons will not be able to take part in the conference.
Participation in gala dinner 30.08.24 – € 100
Participation in other evening meals 28.08, 29.08, 31.08 – € 225
Participation in lunches 29-31.08 – € 175
Please register early, as the registration will be closed when it becomes oversubscribed before the deadline.
In case of any problems with registration or payment, please contact adam.krawczyk@whynottravel.pl
Abstract Submission
Abstract submission deadline:
May 20th 2024 (if you want to be considered for an oral presentation)
June 30th 2024 (only poster presentations)
Only registered participants are eligible to submit an abstract which must be completed online.
Abstracts should not exceed 350 words.
When submitting you can choose whether to apply for a poster, oral presentation, or both. An evaluation process will take place and abstracts selected for oral presentation will be announced after the registration deadline. Early-stage researchers are also encouraged to sign up for an oral presentation.
Invited speakers
Rodrigo Bermejo
Margarita Salas Centre for Biological Research,
Spain
Luis Blanco
Centro de Biología Molecular Severo Ochoa,
Spain
Peter Burgers
Washington University School of Medicine, USA
William Copeland
NIEHS
National Institutes of Health
USA
Marc Delarue
Institut Pasteur, France
Sylvie Doublie
University of Vermont, USA
Vanesa Gottifredi
Fundación Instituto Leloir, Argentina
Erik Johansson
Umeå University, Sweden
Patricia Kannouche
CNRS-Gustave Roussy, France
Thomas Kunkel
NIEHS
National Institutes of Health
USA
Tatiana Moiseeva
Tallinn University of Technology, Estonia
Marcin Nowotny
International Institute of Molecular and Cell Biology, Poland
Dale A. Ramsden
University of North Carolina, USA
Polina Shcherbakova
University of Nebraska Medical Center, USA
Fred and Pamela Buffett
Cancer Center and Eppley Institute, USA
Rick Wood
University of Texas MD Anderson Cancer Center, USA
Wei Yang
NIDDK
National Institutes of Health
USA
Joseph Yeeles
Medical Research Council, UK
The meeting will include plenary, invited and selected talks, as well as poster presentations.
Program
For travel planning purposes,
the meeting will start at 13:00 on August 28th and conclude at 22:00 after the dinner on August 31st.
Program of the 7th DNA Polymerases Meeting
|
August 28th - Day 1 |
|
Registration (13:00 – 14:45) Opening speech Replicative DNA polymerases and the replisome
Coffee break
Welcome reception |
|
August 29th - Day 2 |
|
Replicative DNA polymerases and the replisome
Function and regulation of DNA polymerases
Coffee break
Lunch DNA polymerases in DNA damage repair and tolerance
Poster session Dinner |
|
August 30th - Day 3 |
|
DNA polymerases in DNA damage repair and tolerance
Coffee break DNA polymerases in DNA damage repair and tolerance
Lunch Free time and sightseeing Gala dinner |
|
August 31st - Day 4 |
|
DNA polymerases and diseases
Coffee break DNA polymerases from viruses
Lunch DNA polymerases and biotechnology
Coffee break Sponsors' talks Concluding remarks Dinner |
August 28th - Day 1
| 13:00-14:45 | Registration |
| 14:45-15:00 | Opening speech |
| Replicative DNA polymerases and the replisome - 1 Chair: Peter Burgers |
|
| 15:00-15:25 | Thomas Kunkel Eukaryotic nuclear DNA replication fidelity |
| 15:25-15:50 | Erik JohanssonHow Pol epsilon, a family B polymerase, selects and incorporates nucleotides |
| 15:50-16:05 | Johann Jonas Roske Molecular snapshots of daughter strand synthesis and proofreading by the human leading-strand polymerase Pol ε |
| 16:05-16:20 | Alain Nicolas DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in S. cerevisiae |
| 16:20-16:35 | Janice PataStructure and kinetics mechanism of S. aureus DnaE: implications for the initiation of Okazaki fragments in Gram-positive bacteria |
| 16:45-17:15 | Coffee break |
| Replicative DNA polymerases and the replisome - 2 Chair: Polina Shcherbakova |
|
| 17:15-17:40 | Rodrigo BermejoFunctional architecture of replication fork protection |
| 17:40-17:55 | Markel Martínez-CarranzaReplication Protein A interactions with DNA polymerases within the archaeal replisome |
| 17:55-18:10 | Tahir Tahirov Human primosome requires replication protein A when copying DNA with inverted repeats |
| 18:20-21.00 | Welcome reception |
August 29th - Day 2
| Replicative DNA polymerases and the replisome - 3 Chair: Erik Johansson |
|
| 09:00-09:25 | Peter Burgers The Rev1-DNA polymerase ζ mutasome |
| 09:25-09:50 | Joseph Yeeles The eukaryotic replisome: structure and mechanism |
| 09:50-10:05 | Michal Dmowski Impact of defective Dpb2 subunit of DNA Pol ε on DNA replication and cell cycle progression in Saccharomyces cerevisiae |
| 10:05-10:20 | Emily Beckwitt Recruitment and assembly of replication stress checkpoint signaling factors |
| 10:30-11:00 | Coffee break |
| Function and regulation of DNA polymerases - 1 Chair: Luis Blanco |
|
| 11:00-11:25 | Patricia Kannouche Regulation of the mammalian DNA polymerase zeta in response to genotoxic stress |
| 11:25-11:40 | Justyna McIntyre Regulation of the cellular level of polymerase ɩ |
| 11:40-11:55 | Leonardo Betancurt-AnzolaProofreading mechanism for family D DNA polymerases |
| 11:55-12:10 | Whitney Yin An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol gamma |
| 12:15-13:15 | Lunch |
| Function and regulation of DNA polymerases - 2 Chair: Joann Sweasy |
|
| 13:15-13:40 | Vanesa Gottifredi The relevance of the levels of the cyclin kinase inhibitor p21 for the nascent DNA replication speed and the control of the genomic stability of cells |
| 13:40-13:55 | Kristin Eckert polymerase epsilon and delta holoenzymes show wide ranging inhibition at G-quadrulexes the human genome |
| 13:55-14:10 | Lisanne Spenkelink Single-molecule visualisation of polymerase dynamics at G-quadrulexes |
| 14:10-14:25 | Deepak Thankappan Nair New answers to old questions regarding DNA synthesis by DNA polymerases |
| 14:35-15.05 | Coffee break |
| DNA polymerases in DNA damage repair and tolerance - 1 Chair: Dale Ramsden |
|
| 15:05-15:30 | Joann Sweasy Fidelity of DNA polymerase beta |
| 15:30-15:45 | Julien Duxin Catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis |
| 15:45-16:00 | Simone Sabbioneda The catalytic activity of DNA polymerase η prevents G-quadruplexes accumulation in vivo and triggers the DNA damage response upon their stabilization. |
| 16:00-16:20 | Group photo |
| 16:20-19:00 | Coffee break and Poster session |
| 19:00-20.30 | Dinner |
August 30th - Day 3
| DNA polymerases in DNA damage repair and tolerance - 2 Chair: William Copeland |
|
| 09:00-09:25 | Dale A Ramsden Requirement for polymerases theta and delta in alternative end joining |
| 09:25-09:50 | Wei Yang Replication forks in bypassing DNA lesions |
| 09:50-10:05 | David Szüts Translesion polymerase choice determines the mutagenic outcome at replication-stalling lesions |
| 10:05-10:20 | Dmitry Korzhnev Adaptable interactions of translesion synthesis scaffold proteins |
| 10:20-10:35 | Česlovas Venclovas Common themes in architecture and interactions of prokaryotic PolB2 and Pol V mutasomes |
| 10:40-11:10 | Coffee break |
| DNA polymerases in DNA damage repair and tolerance - 3 Chair: Marc Delarue |
|
| 11:10-11:35 | Sylvie Doublie Functional consequences of domain self-assembly in DNA polymerase θ: A tale of protein oligomerization and the limitations of AI |
| 11:35-12:00 | Rick Wood Biochemical reactions mediated by DNA polymerase theta |
| 12:00-12:15 | Kei-ichi Takata The tolerance of DNA damage by human mus308 homologs, POLQ and HELQ |
| 12:15-12:30 | Irina Bezsonova A novel connection between Y-family DNA polymerases and the nucleotide excision repair proteins |
| 12:30-12:45 | Jordane Goulas Unraveling the role of the accessory subunit REV7 in the regulation of DNA polymerase zeta bypass activity in mammalian cells |
| 12:55-14:00 | Lunch |
| 14:00-15:00 | Additional time for discussion by posters |
| 15:00-18:00 | Free time and sightseeing |
| 19:00-23:00 | Gala dinner |
August 31th - Day 4
| DNA polymerases from viruses Chair: Wei Yang |
|
| 09:30-09:55 | Marc DelarueStructural studies of large DNA polymerases from phages by cryo-EM |
| 09:55-10:20 | Marcin Nowotny Mechanisms of reverse transcriptases in viral replication and antiphage responses |
| 10:20-10:35 | Michal Roman Szymanski Some like it cold: characterization of DNA polymerase from wastewater bacteriophage vB_EfaS-271 |
| 10:45-11:15 | Coffee break |
| DNA polymerases and diseases Chair: Patricia Kannouche |
|
| 11:15-11:40 | William Copeland Structural insights into mitochondrial DNA replication and disease relevance |
| 11:40-11:55 | Maria Falkenberg Molecular consequences of POLG mutations and new avenues of treatment |
| 11:55-12:20 | Polina Shcherbakova DNA polymerase ε variants in cancers: a novel genomic signature and discovery of new driver alleles |
| 12:20-12:35 | Helmut Pospiech Targeting metabolic pathways important for human cancer cells with an ultramutator phenotype |
| 12:35-12:50 | Penny Beuning Classification and characterization of human DNA polymerase kappa cancer-associated single-nucleotide polymorphisms |
| 13:05-13:20 | Meindert Lamers Deciphering DnaE2, the polymerase that drives antibiotic resistance in M. tuberculosis |
| 13:30-14:40 | Lunch |
| DNA polymerases and biotechnology Chair: Richard Wood |
|
| 14:40-15:05 | Luis Blanco New enzymes and strategies to optimize isothermal amplification of nucleic acids |
| 15:05-15:20 | Emma Verver Polymerases and replication processes in action: observing individual molecules in real time |
| 15:20-15:35 | Kyle VrtisAdvancing rolling circle and whole genome amplification applications with a newly engineered phi29 DNA polymerase |
| 15:35-15:50 | Kelly Zatopek Everybody makes mistakes: Utilizing high-throughput sequencing to determine replicative DNA polymerase fidelity |
| 15:50-16:20 | Poster awards and next meeting planning |
| 16:20-16:35 | Concluding remarks |
| 16:35-18:00 | Dinner |
Sponsors
Venue
The conference will take place in the Hotel Verte Warsaw (https://hotelverte.com/en/) located near the Royal Castle in the historical heart of the city – Warsaw’s Old Town. The hotel is handicap accessible.
Conference participants will get special prices for hotel rooms with significant discount.
Accomodation
The conference will take place in the Hotel Verte Warsaw (https://hotelverte.com/en/) located near the Royal Castle in the historical heart of the city – Warsaw’s Old Town. The hotel is handicap accessible.
Conference participants will get significant discount to book rooms at Hotel Verte using the link:
Some other hotels in the vicinity of the conference venue:
• Hotel Bellotto (*****), Senatorska 13/15
https://www.hotelbellotto.pl
• Hotel Bristol Warsaw (*****), Krakowskie Przedmieście 42/44
https://www.marriott.com/en-us/hotels/wawlc-hotel-bristol-a-luxury-collection-hotel-warsaw/overview/
• Hotel Warszawa (*****), pl. Powstańców Warszawy 9
https://www.warszawa.hotel.com.pl
• Hotel Le Regina Warsaw (*****), Kościelna 12
https://www.mamaisonleregina.com/pl/
• Sofitel Warszawa Victoria (*****), Królewska 11
https://www.sofitel-victoria-warsaw.com
• Hotel Indigo Warsaw (****), Smolna 40
https://www.ihg.com/hotelindigo/hotels/gb/en/warsaw/wawid/hoteldetail
• Ibis Hotel Stare Miasto (***), Muranowska 2
https://ibis-warszawa-stare-miasto.hotel-warsaw.net/en/#main
• Hotel Gromada Warszawa Centrum (***), Pl. Powstańców Warszawy 2
https://www.gromada.pl/en/about-the-hotel-page-155684
• Castle Inn (***), Świętojańska 2
https://castleinn.pl/
Visiting Warsaw
Warsaw was voted European Best Destination 2023
https://www.europeanbestdestinations.com/european-best-destinations-2023/#
Here you can get some further info on Warsaw
https://youtu.be/SNte2O6OFao
https://www.youtube.com/watch?v=xVPXO6Dx0xU
You can find more at the official Warsaw Tourist Information webpage
https://warsawtour.pl/en/main-page/
Sightseeing options
Participation is optional.
All trips are walking tours.
Also available for accompanying persons.
Date: 30 August 2024 (Friday), 15:00 – 18:00
Meeting spot: Foyer of the Verte Hotel
1. OPTION: Old Town and the Royal Route
Walk through the Old Town from Barbican, part of the city walls, to the Royal Castle Square through the Old Town Market Square with the monument to the Warsaw Mermaid, St. John Cathedral and the Royal Castle (no entrance) on the way. Then continue the walk through the Royal Route. Along the way there are many historic buildings, churches and monuments for example: monument to the poet Adam Mickiewicz, the Presidential Palace, the oldest Warsaw hotels Bristol and Europejski, Piłsudski Square with the Tomb of the Unknown Soldier, the Campus of the Warsaw University, the Church of Holy Cross where the heart of Frederic Chopin is buried. End of the tour by the monument of astronomer Nicolaus Copernicus.
Price per person – 20 euro
2. OPTION: Old Town and the Royal Castle
Visiting the interiors of the Royal Castle, which in the Middle Ages was the seat of local princes. Since the 16th century it has been the official seat of Polish kings and parliament. Completely destroyed during World War II, it was painstakingly rebuilt. Then the walk through the Old Town to the Barbican, part of the city walls. Along the way St. John Cathedral and the Old Town Market Square with the monument to the Warsaw Mermaid.
Price per person – 35 euro
3. OPTION: Polin – The Museum of the History of Polish Jews
Walk towards Krasiński Square. Short history of fights in Warsaw during World War II by the Warsaw Uprising monument. Continue the walk through Krasiński park towards former Jewish Ghetto. The Holocaust history and the history of the Jewish Uprosing by the main Monument to the Ghetto heroes. Visiting the Polin museum and the 1000-year-old history of Polish Jews.
Price per person – 25 euro
Attention! The distance from the Verte Hotel to the Polin Museum is about 2 km.
4. OPTION: Frederic Chopin’s Warsaw
Warsaw is called the city of the musical genius Fryderyk Chopin because he spent half of his life here. Walk along Krakowskie Przedmieście Street. Along the way there are places related to the composer’s life, such as the current Presidential Palace, where Chopin gave his first public concert at the age of 8, or the former apartments of Chopin and his family, the Church of the Holy Cross, where the urn with the heart of the pianist, who died in Paris, rests. At the end of the tour, visit the Fryderyk Choin Museum, which tells the story of his entire life, also in exile.
Price per person – 25 euro
Attention! The distance from the Verte Hotel to the Fryderyk Chopin Museum is about 2 km.